Description
OX40L (CD252, CD134L) is a membrane-expressed cytokine that belongs to the TNF ligand family. It acts as a costimulator through interaction with its ligand OX40 on T cells, stimulating T cell activation, proliferation and cytokine production. OX40L is expressed on antigen presenting cells including B cells, dendritic cells, mast cells and endothelium. Multimeric OX40L is a high activity construct in which two trimeric OX40L ligands are artificially linked via the collagen domain of mouse ACRP30. This construct very effectively activates T cell proliferation